Built in the 15th and 16th centuries, in Manueline-Mudejar and Renaissance style, to replace an earlier Gothic temple, of which there are still some remnants. It was adjacent to the Royal Palace, and seen as a Royal Church therefore important ceremonies were held there such as the marriage of Prince Afonso to Isabel of Castilla in 1490.
The frontage of the church is characterized by the volumetry of the crownings and the portal is decorated with the royal emblems of the kings John II and Manuel I. The interior has a single nave, rectangular in shape and in the form of a Latin cross, emphasizing the Baroque high-altar and the Chapel of the Third Order of Saint Francis. The greatest popular curiosity resides in the Chapel of Bones, of three naves completely covered in human bones (17th century).
The convent was demolished in the late 19th century.