Founded in the Middle Ages, next to the Moorish quarter, underwent a major renovation in the 16th century. His chaplain was Mestre André de Resende.
Inspired by late renaissance, with Tridentine influences. The rectangular nave's body is decorated with polychrome tile panels, forming precious collections of varied motifs, carpet, brutes, labels, etc., from the 17th century; the ribbed vault is painted in frescoes (1691). Religious themed-paintings, from the extinct Convent of Santa Monica, are displayed on the altar of the main chapel,